Drug-induced Hypersensitivity Syndrome Following Meningoencephalitis Associated with Human Herpes Virus-6

Human herpes virus 6 encephalitis in allopurinol-induced hypersensitivity syndrome.

Hypersensitivity syndrome is one of the most severe forms of drug eruption, and is characterized by a severe, potentially lethal, multiorgan involvement. Recently, reactivation of human herpesvirus 6 (HHV-6) has been suggested to be involved in this syndrome, although the exact role of HHV-6 remains elusive. In addition to exanthem subitum, neurological illnesses, such as infantile febrile illn...

[Sulfasalazine-induced hypersensitivity syndrome associated with human herpesvirus 6 reactivation and induction of antiphospholipid syndrome].

Drug-induced hypersensitivity syndrome is a toxicoderma with systemic involvement. Suspicion of this disorder obliges rapid withdrawal of the suspected drug, which may have been introduced up to 3 months earlier. Screening for human herpesvirus (HHV) 6 reactivation is important both for its diagnostic value and for its association with a poor prognosis. Reactivation of this virus is not a contr...

The Link between Hypersensitivity Syndrome Reaction Development and Human Herpes Virus-6 Reactivation

Background. There are challenges in the clinical diagnosis of drug-induced injury and in obtaining information on the reactivation of human herpes viruses (HHV) during idiosyncratic adverse drug reactions. Objectives. (i) To develop a unified list of drugs incriminated in drug-induced hepatotoxicity and severe cutaneous reactions, in which drug hypersensitivity leads to HHV-6 reactivation and f...

Herpes Simplex Virus Meningoencephalitis in A Methamphetamin User

Teicoplanin induced drug hypersensitivity syndrome.

We thank the many women who completed questionnaires for this study. We are grateful to the staff at the collaborating breast screening units and at the Million Women Study coordinating centre for their valuable contribution to the study and to Adrian Goodill for producing the figure. Contributors: Emily Banks, Gillian Reeves, Valerie Beral, and Julietta Patnick had the original idea for the st...